참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylamine | HCID 674 | — |
| 반응물 | 2-Bromo-1-(4-(difluoromethoxy)phenyl)ethan-1-one | HCID 703496 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Dimethylamino-4'-difluoromethoxyacetophenone | HCID 18980927 | 44.4% |
반응 단계
To 7.5 g (165 mmole) of anhydrous dimethylamine in 50 ml of methylene chloride and cooled to -30° C. was added a solution of 20 g (664 mmole) of 2-bromo-4'-difluoromethoxyacetophenone in 50 ml of methylene chloride. After the addition was complete the reaction was allowed to warm to 20° C. Concentration in vacuo, partitioning between diethyl ether and 1M aqueous sodium hydroxide, washing with brine, drying over anhydrous magnesium sulfate, and reconcentration in vacuo yielded 16.8 g of 2-dimethylamino-4'-difluoromethoxyacetophenone, an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05109014 |
|---|
| 출처 데이터셋 | uspto-grants-1992_04 |
|---|
| ORD ID | ord-e1945386f85048898b7fe2905c06b3a4 |
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| 출처 메모 | uspto-grants-1992_04 |
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