反应详情

温度

20 °C

To 7.5 g (165 mmole) of anhydrous dimethylamine in 50 ml of methylene chloride and cooled to -30° C. was added a solution of 20 g (664 mmole) of 2-bromo-4'-difluoromethoxyacetophenone in 50 ml of methylene chloride. After the addition was complete the reaction was allowed to warm to 20° C. Concentration in vacuo, partitioning between diethyl ether and 1M aqueous sodium hydroxide, washing with brine, drying over anhydrous magnesium sulfate, and reconcentration in vacuo yielded 16.8 g of 2-dimethylamino-4'-difluoromethoxyacetophenone, an oil.

1. additionAfter the addition
2. concentrationConcentration in vacuo
3. custompartitioning between diethyl ether and 1M aqueous sodium hydroxide
4. washwashing with brine
5. dry with materialdrying over anhydrous magnesium sulfate, and reconcentration in vacuo