Diethyl Ether → 2-(N-methyl-N-(methoxycarbonyl)amino)-4'-propoxyacetophenone

HRID 1031242Notes

Reaction equation

[CH3:1][N:2]([CH2:7][C:8]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH:17](F)F)=[CH:12][CH:11]=1)=[O:9])[C:3]([O:5][CH3:6])=[O:4].[CH2:20](OCC)[CH3:21]>>[CH3:1][N:2]([CH2:7][C:8]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH2:17][CH2:20][CH3:21])=[CH:12][CH:11]=1)=[O:9])[C:3]([O:5][CH3:6])=[O:4]

Participants

Reactant 2

HCID 3283Diethyl Ether

HCID 189809882-(N-methyl-N-(methoxycarbonyl)amino)-4'-difluoromethoxyacetophenone

Product 1

HCID 197865212-(N-methyl-N-(methoxycarbonyl)amino)-4'-propoxyacetophenone

Procedure

By substantially following the procedure given in Example 19b, substituting 2-(N-methyl-N-(methoxycarbonyl)amino)-4'-propoxyacetophenone for 2-(N-methyl-N-(methoxycarbonyl)amino)-4'-difluoromethoxyacetophenone and using diethyl ether as solvent and continuing with Example 19dii the expected compound, an oil, bp 150°-160° C. at 0.2 torr, was obtained.

Sources & evidence

ORD record: ord-be85aa39c7c34273b5ee1e085c23ba7b
Source dataset: uspto-grants-1992_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05109014

Reaction notes

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