Acetic Acid → HCID 14152234, compound

HRID 1031381Notes

Reaction equation

HRID 1031381 reaction equation
[Na].[CH3:2][OH:3].[Cl:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[C:6]=1[NH:12][S:13]([C:16]1[N:26]=[C:19]2[N:20]=[C:21](Cl)[CH:22]=[C:23](Cl)[N:18]2[N:17]=1)(=[O:15])=[O:14].[C:27]([OH:30])(=O)C>>[Cl:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[C:6]=1[NH:12][S:13]([C:16]1[N:26]=[C:19]2[N:20]=[C:21]([O:30][CH3:27])[CH:22]=[C:23]([O:3][CH3:2])[N:18]2[N:17]=1)(=[O:15])=[O:14]

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 887MethanolHCID 5360545SodiumHCID 14152233HCID 14152233, compound

Product 1

HCID 14152234HCID 14152234, compound

Procedure

Sodium (683 mg, 29.7 mmol) was added to 30 ml of methanol under nitrogen and allowed to react. The resulting solution was cooled and 4.06 g (9.83 mmol) of N-(2,6-dichlorophenyl)-5,7-dichloro-1,2,4-triazolo[1,5-a]-pyrimidine-2-sulfonamide were added with stirring. After one hour, 2 ml of acetic acid was added and the mixture was poured into about 150 ml of ice water. The solids present were collected by filtration and dried to obtain 3.21 g (88 percent of theory) of the title compound, which is a white powder that melts at 232°-4° C.

Workup

  1. customto react
  2. temperatureThe resulting solution was cooled
  3. filtrationThe solids present were collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-1767c4b2535741c592d5865a93955f79
Source dataset
uspto-grants-1990_09
Patent number
US04954163

Reaction notes

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