1,3-Difluoro-2-nitrobenzene → 2-(2-Chloro-4-trifluoromethylphenoxy)-6-fluoronitrobenzene

HRID 1031396Notes

Reaction equation

HRID 1031396 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[N+:9]([O-:11])=[O:10].[Cl:12][C:13]1[CH:18]=[C:17]([C:19]([F:22])([F:21])[F:20])[CH:16]=[CH:15][C:14]=1[OH:23]>>[Cl:12][C:13]1[CH:18]=[C:17]([C:19]([F:20])([F:21])[F:22])[CH:16]=[CH:15][C:14]=1[O:23][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[N+:9]([O-:11])=[O:10]

Participants

3

Reactant 2

HCID 879221,3-Difluoro-2-nitrobenzeneHCID 27366032-Chloro-4-(trifluoromethyl)phenol

Product 1

HCID 541374142-(2-Chloro-4-trifluoromethylphenoxy)-6-fluoronitrobenzeneYield 47%

Procedure

This material was prepared in 47% yield from 2,6-difluoronitrobenzene and 2-chloro-4-trifluoromethylphenol following the general procedure outlined in Example 104. The product was isolated as an oil which was characterized by IR and 1H NMR spectroscopy.

Workup

  1. customThe product was isolated as an oil which

Sources & evidence

ORD record
ord-d4b3547b567343b3ba507dca6f1263f8
Source dataset
uspto-grants-1990_09
Patent number
US04954163

Reaction notes

Loading…