反应详情

2 g. (9.7 mmole) 4,4-dimethyl-6,7-diamino-1,2,3,4-tetrahydroquinolin-2-one (see Example 13 a)), 1.67 g. (9.7 mmole) 4-(lH-imidazol-1-yl)-benzaldehyde, 0.17 g. p-toluenesulphonic acid and 120 ml. ethanol were mixed together and heated under reflux for 3 hours while passing through air. The evaporation residue was suspended in water, neutralised with 2N aqueous ammonia and recrystallised from methanol to give 1.7 g. (49% of theory) of the title compound; m.p. >300° C. EXAMPLE 19

1. temperatureheated
2. temperatureunder reflux for 3 hours
3. customrecrystallised from methanol
4. customto give 1.7 g