Hydrochloric Acid → HCID 23171025, compound

HRID 1031448Notes

Reaction equation

HRID 1031448 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[NH2:12])[NH:8][C:7](=[O:13])[CH2:6][C:5]2([CH3:15])[CH3:14].[C:16](OC(=O)C)(=O)[CH3:17].Cl>C(O)C>[CH3:16][C:17]1[NH:1][C:2]2=[CH:3][C:4]3[C:5]([CH3:15])([CH3:14])[CH2:6][C:7](=[O:13])[NH:8][C:9]=3[CH:10]=[C:11]2[N:12]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 19896766HCID 19896766, compound

Product 1

HCID 23171025HCID 23171025, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3.1 g. 6,7-diamino-4,4-dimethyl-1,2,3,4-tetrahydro- quinolin-2-one and 2.8 ml. acetic anhydride were stirred in 50 ml. ethanol for 30 minutes at ambient temperature. 20 ml. concentrated hydrochloric acid were then added thereto and the reaction mixture refluxed for 18 hours. The solvent was removed in a vacuum and the residue was dissolved in water, rendered alkaline with ammonia, filtered off with suction and washed with water. After recrystallisation from ethyl acetate, there were obtained 2.4 g. of the title compound; m.p. 290 294° C.

Workup

  1. temperaturethe reaction mixture refluxed for 18 hours
  2. customThe solvent was removed in a vacuum
  3. dissolutionthe residue was dissolved in water
  4. filtrationfiltered off with suction
  5. washwashed with water
  6. customAfter recrystallisation from ethyl acetate
  7. customthere were obtained 2.4 g

Sources & evidence

ORD record
ord-120cf148a07f473b9652b4543499d027
Source dataset
uspto-grants-1990_09
Patent number
US04954498

Reaction notes

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