1-Piperazinecarboxylic acid, ethyl ester → HCID 14459475, compound

HRID 1031473Notes

Reaction equation

HRID 1031473 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]([CH3:15])[CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][C:3]=1[C:16]#[N:17].[CH2:18]([O:20][C:21]([N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)=[O:22])[CH3:19]>>[C:16]([C:3]1[CH:4]=[C:5]([C:8]2[CH:9]([CH3:15])[CH2:10][C:11](=[O:14])[NH:12][N:13]=2)[CH:6]=[CH:7][C:2]=1[N:26]1[CH2:25][CH2:24][N:23]([C:21]([O:20][CH2:18][CH3:19])=[O:22])[CH2:28][CH2:27]1)#[N:17]

Participants

3

Reactant 2

HCID 84311-Piperazinecarboxylic acid, ethyl esterHCID 14459458HCID 14459458, compound

Product 1

HCID 14459475HCID 14459475, compound

Procedure

1.5 g (6.1 mmol) of the chlorocyanophenylpyridazinone from stage (a) and 5 ml of 1-ethoxycarbonylpiperazine are together heated to 170° C. for 5 hours. After the reaction mixture has cooled, it is poured out on water and extracted with ethyl acetate and the combined organic phases are concentrated by evaporation under vacuum.

Workup

  1. temperatureAfter the reaction mixture has cooled
  2. additionit is poured out on water
  3. extractionextracted with ethyl acetate
  4. concentrationthe combined organic phases are concentrated by evaporation under vacuum

Sources & evidence

ORD record
ord-0545f04a3f094bdf9d9c7761f0d58af3
Source dataset
uspto-grants-1990_09
Patent number
US04954501

Reaction notes

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