反应详情

温度

0 °C

A mixture of the formamide intermediate, prepared above, (3.55 g) in 6 N HCl (30 mL) was heated at reflux for 1/2 h. The reaction was cooled to 0° C., made basic with 10N NaOH, and extracted with CH2Cl2 (3×50 mL). The combined organic layers were washed with sat. NaCl solution, dried with anhydrous K2CO3, filtered, and concentrat.ed under reduced pressure to afford 1-(6-methoxy-2-pyridinyl)piperazine (2.72 g; 83%).

1. temperaturewas heated
2. temperatureat reflux for 1/2 h
3. extractionextracted with CH2Cl2 (3×50 mL)
4. washThe combined organic layers were washed with sat. NaCl solution
5. dry with materialdried with anhydrous K2CO3
6. filtrationfiltered