Benzyl Alcohol → HCID 53651325, compound

HRID 1031505Notes

Reaction equation

[CH2:1]([OH:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:10]1[CH:15]=[CH:14][C:13]([C:16]([C:26]2[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[C:28]([O:34][CH3:35])[CH:27]=2)=[CH:17][C:18]([N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)=[O:19])=[CH:12][N:11]=1.[H-].[Na+]>>[CH2:1]([O:8][C:10]1[CH:15]=[CH:14][C:13]([C:16]([C:26]2[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[C:28]([O:34][CH3:35])[CH:27]=2)=[CH:17][C:18]([N:20]2[CH2:21][CH2:22][O:23][CH2:24][CH2:25]2)=[O:19])=[CH:12][N:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 244Benzyl Alcohol

HCID 24758Sodium hydride

HCID 53647660HCID 53647660, compound

Product 1

HCID 53651325HCID 53651325, compoundYield 76%

Procedure

In the same manner as in Example 2, using benzyl alcohol (554 mg), 4-[3-(2-chloro-5-pyridyl)-3-(3,4-dimethoxyphenyl)acryloyl]morpholine (1 g) and 60% sodium hydride (205 mg), 4-[3-(2-benzyloxy-5-pyridyl)-3-(3,4-dimethoxyphenyl)acryloyl]morpholine (Compound No.63) (0.9 g) was obtained as a resinous solid.

Sources & evidence

ORD record: ord-93529ac29eae4a2a8f028e21331b2df8
Source dataset: uspto-grants-1990_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04954497

Reaction notes

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