反应详情

Starting from 1-methyl-3-phenyl-5-pyrazolamine and ethyl-2-(2,5-dimethylbenzyliden)acetoacetate in equimolar proportions. The crude reaction product is taken up with ethyl ether, washed with 2% H2SO4, water, and then 5% NaHCO3 until neutralization of the mother liquors. After drying over Na2SO4 the hydrochloride of the title compound is obtained by reacting with HCl/ethyl ether. Crystallization from isopropanol/ethyl ether.

1. customThe crude reaction product
2. washwashed with 2% H2SO4, water
3. dry with materialAfter drying over Na2SO4 the hydrochloride of the title compound
4. customis obtained
5. customCrystallization from isopropanol/ethyl ether