HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-3-phenyl-1H-pyrazol-5-amine → 4,7-dihydro-1,6-dimethyl-4-(2,5-dimethylphenyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-5-carboxylic acid ethyl ester, hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-3-phenyl-1H-pyrazol-5-amine | HCID 517779 | — |
| Reactant | Ether hydrochloride | HCID 10953452 | — |
| Reactant | Ethyl-2-(2,5-dimethylbenzyliden)acetoacetate | HCID 54285001 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 4,7-dihydro-1,6-dimethyl-4-(2,5-dimethylphenyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridin-5-carboxylic acid ethyl ester, hydrochloride | HCID 137225461 | — |
Reaction Steps
Starting from 1-methyl-3-phenyl-5-pyrazolamine and ethyl-2-(2,5-dimethylbenzyliden)acetoacetate in equimolar proportions. The crude reaction product is taken up with ethyl ether, washed with 2% H2SO4, water, and then 5% NaHCO3 until neutralization of the mother liquors. After drying over Na2SO4 the hydrochloride of the title compound is obtained by reacting with HCl/ethyl ether. Crystallization from isopropanol/ethyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04954508 |
| Source dataset | uspto-grants-1990_09 |
| ORD ID | ord-bde35e311a2043e39e8790be6956d6ce |
| Source note | uspto-grants-1990_09 |