1-Tert-butylpiperazine → HCID 488652, compound

HRID 1031555Notes

Reaction equation

[CH3:1][C:2]([N:5]1[C:14]2[C:9](=[CH:10][C:11]([F:16])=[C:12](Cl)[CH:13]=2)[C:8](=[O:17])[C:7]([C:18]([OH:20])=[O:19])=[CH:6]1)([CH3:4])[CH3:3].[CH3:21][C:22]([N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1)([CH3:24])[CH3:23]>CN1CCCC1=O>[CH3:21][C:22]([N:25]1[CH2:30][CH2:29][N:28]([C:12]2[CH:13]=[C:14]3[C:9]([C:8](=[O:17])[C:7]([C:18]([OH:20])=[O:19])=[CH:6][N:5]3[C:2]([CH3:4])([CH3:3])[CH3:1])=[CH:10][C:11]=2[F:16])[CH2:27][CH2:26]1)([CH3:24])[CH3:23]

Participants

Conditions

Temperature: 100 °C

Procedure

A mixture of 0.45 g (1.51 mmoles) 1-(1,1-dimethylethyl)-1,4-dihydro-7-chloro-6-fluoro-4-oxo-3-quinolinecarboxylic acid and 0.65 g (4,56 mmoles) 1-(1,1-dimethylethyl)piperazine in 2 mL N-methylpyrrolidone were heated 5 hours at 100° C. The solvent was evaporated under reduced pressure. The residue was tritured in water. The precipitate was recrystallized in ethanol to give 0.136 g of titled compound. MP>270° C.

Workup

customThe solvent was evaporated under reduced pressure
customThe precipitate was recrystallized in ethanol

Sources & evidence

ORD record: ord-5c09249aae9447ad8dbbb706c753c67e
Source dataset: uspto-grants-1990_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04954507

Reaction notes

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