Hydrazine hydrate (1:1) → HCID 10085886, compound

HRID 1031572Notes

Reaction equation

HRID 1031572 reaction equation
C1(=O)[N:5]([CH2:6][CH:7]2[CH2:12][N:11]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:10][CH2:9][N:8]2[CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)C(=O)C2=CC=CC=C12.O.NN>C(O)C.C(OCC)C>[NH2:5][CH2:6][CH:7]1[CH2:12][N:11]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:10][CH2:9][N:8]1[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

5

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 14839581HCID 14839581, compound

Product 1

HCID 10085886HCID 10085886, compoundYield 101.5%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 3283Diethyl EtherSolvent

Procedure

The solution of 4.25 g (10 mmol) of 2-phtalimidomethyl-1,4-di-phenylmethyl piperazine and 1.25 g (25 mmol) of hydrazine monohydrate in 50 ml ethanol was stirred 2 hours under reflux. Insoluble material was filtered off. The ethanol layer was evaporated to dryness to afford a residue taken up in 20 ml ethyl ether, filtered again and evaporated to give 3.0 g of the title compound as an oil.

Workup

  1. temperatureunder reflux
  2. filtrationInsoluble material was filtered off
  3. customThe ethanol layer was evaporated to dryness
  4. customto afford a residue
  5. filtrationfiltered again
  6. customevaporated

Sources & evidence

ORD record
ord-711f7f4e2f23492597d3734665a93091
Source dataset
uspto-grants-1990_09
Patent number
US04954507

Reaction notes

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