Dicyclohexylcarbodiimide → HCID 67869533, compound

HRID 1031614Notes

Reaction equation

HRID 1031614 reaction equation
[CH3:1][N:2]([CH3:15])[CH:3]([CH:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][CH2:7][NH:6]1)[CH3:4].[Cl:16][C:17]1[CH:18]=[C:19]([CH2:24][C:25](O)=[O:26])[CH:20]=[CH:21][C:22]=1[Cl:23].C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[CH3:15][N:2]([CH3:1])[CH:3]([C:5]1([C:25](=[O:26])[CH2:24][C:19]2[CH:20]=[CH:21][C:22]([Cl:23])=[C:17]([Cl:16])[CH:18]=2)[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][CH2:7][NH:6]1)[CH3:4]

Participants

5

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 798743,4-Dichlorophenylacetic acidHCID 21274546HCID 21274546, compound

Product 1

HCID 67869533HCID 67869533, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared as Ex. No. 1, from 2.7 g (13.30 mmoles) of 1- dimethylamino-eth-1-yl-1,2,3,4-tetrahydroisoquinoline (diastereoisomeric mixture), 3.05 g (15.00 mmoles) of 3,4-dichlorophenylacetic acid and 4.2 g (20.39 mmoles) of dicyclohexylcarbodiimide, in 100 ml of dry methylene chloride.

Workup

  1. customPrepared as Ex

Sources & evidence

ORD record
ord-8eeb33b8cff641c4a2de495b77baf8a5
Source dataset
uspto-grants-1990_09
Patent number
US04954509

Reaction notes

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