Triethylamine → HCID 22168068, compound

HRID 1031617Notes

Reaction equation

HRID 1031617 reaction equation
Br.Br.[N:3]1([CH2:9][CH:10]2[C:19]3[C:14](=[C:15]([OH:20])[CH:16]=[CH:17][CH:18]=3)[CH2:13][CH2:12][NH:11]2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.CCN(CC)CC.[F:28][C:29]([F:41])([F:40])[C:30]1[CH:35]=[CH:34][C:33]([CH2:36][C:37]([Cl:39])=[O:38])=[CH:32][CH:31]=1>C(Cl)(Cl)Cl>[ClH:39].[N:3]1([CH2:9][C:10]2([C:37](=[O:38])[CH2:36][C:33]3[CH:32]=[CH:31][C:30]([C:29]([F:40])([F:28])[F:41])=[CH:35][CH:34]=3)[C:19]3[C:14](=[C:15]([OH:20])[CH:16]=[CH:17][CH:18]=3)[CH2:13][CH2:12][NH:11]2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 148109432-(4-(Trifluoromethyl)phenyl)acetyl chlorideHCID 22168109HCID 22168109, compound

Product 1

HCID 22168068HCID 22168068, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Prepared as Ex. No. 34, from 1.65 g (4.06 mmoles) of 1-(piperidin-1-yl)methyl-5-hydroxy-1,2,3,4-tetrahydroisoquinoline dihydrobromide, 2.6 ml (18.50 mmoles) of Et3N and 2.2 g (9.89 mmoles) of 4-trifluoromethylphenyl acetyl chloride in 30 ml of dry chloroform.

Workup

  1. customPrepared as Ex

Sources & evidence

ORD record
ord-4f4d4defeedb4d0291921fa85938260b
Source dataset
uspto-grants-1990_09
Patent number
US04954509

Reaction notes

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