2-(3,4-Dichlorophenyl)acetyl chloride → HCID 22168097, compound

HRID 1031619Notes

Reaction equation

HRID 1031619 reaction equation
[N:1]1([CH2:6][CH:7]2[C:16]3[C:11](=[C:12]([O:19][CH3:20])[C:13]([O:17][CH3:18])=[CH:14][CH:15]=3)[CH2:10][CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:21][C:22]1[CH:23]=[C:24]([CH2:29][C:30](Cl)=[O:31])[CH:25]=[CH:26][C:27]=1[Cl:28]>C(Cl)(Cl)Cl>[ClH:21].[N:1]1([CH2:6][C:7]2([C:30](=[O:31])[CH2:29][C:24]3[CH:25]=[CH:26][C:27]([Cl:28])=[C:22]([Cl:21])[CH:23]=3)[C:16]3[C:11](=[C:12]([O:19][CH3:20])[C:13]([O:17][CH3:18])=[CH:14][CH:15]=3)[CH2:10][CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 27581492-(3,4-Dichlorophenyl)acetyl chlorideHCID 15005446HCID 15005446, compound

Product 1

HCID 22168097HCID 22168097, compoundYield 105.7%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Prepared as Ex. No. 33, from 1.3 g (4.71 mmoles) of 1-(pyrrolidin-1-yl)methyl-5,6-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 1.1 g (4.92 mmoles) of 3,4-dichlorophenyl acetyl chloride in 40 ml of dry chloroform. The crude product was crystallized from 40 ml of ethyl acetate, to yield 1.3 g of the title compound.

Workup

  1. customPrepared as Ex
  2. customThe crude product was crystallized from 40 ml of ethyl acetate

Sources & evidence

ORD record
ord-5d58168a7ff94930ae6226608b0e1234
Source dataset
uspto-grants-1990_09
Patent number
US04954509

Reaction notes

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