Hydrochloric Acid → HCID 15670949, compound

HRID 1031642Notes

Reaction equation

HRID 1031642 reaction equation
[C:1]([C:3](=[C:9]([C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1)[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1)[CH2:4][CH2:5][C:6]([OH:8])=[O:7])#[N:2].[OH-:26].[Na+].Cl>C(O)CO>[C:1]([C:3](=[C:9]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=1)[C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1)[CH2:4][CH2:5][C:6]([OH:8])=[O:7])(=[O:26])[NH2:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 65913Satigrel

Product 1

HCID 15670949HCID 15670949, compound

Reagents, catalysts & solvents 1

HCID 174Ethylene GlycolSolvent

Procedure

Two grams of the acid obtained in Example 4 was heated with 10 ml of a 5N aqueous solution of NaOH in 50 ml of ethylene glycol at 150° C. for 12 hours. The product mixture was acidified with hydrochloric acid and extracted with ethyl acetate. The extract was treated with the chromatography of silicagel to obtain 0.5 g of the above intended compound.

Workup

  1. extractionextracted with ethyl acetate
  2. additionThe extract was treated with the chromatography of silicagel

Sources & evidence

ORD record
ord-09d4811ce8e446eebcf462eee75c629a
Source dataset
uspto-grants-1990_09
Patent number
US04954523

Reaction notes

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