Hydrochloric Acid → HCID 14722314, compound

HRID 1031693Notes

Reaction equation

HRID 1031693 reaction equation
C([NH:4][C:5]1[C:15]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:14][C:8]2[C:9](=[O:13])[CH2:10][CH2:11][O:12][C:7]=2[CH:6]=1)(=O)C.Cl>C(O)C>[NH2:4][C:5]1[C:15]([O:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[CH:14][C:8]2[C:9](=[O:13])[CH2:10][CH2:11][O:12][C:7]=2[CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14722313HCID 14722313, compound

Product 1

HCID 14722314HCID 14722314, compoundYield 92.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

There were mixed 29.7 g of 7-acetylamino-2,3-dihydro-6-phenoxy-4H-1-benzopyran-4-one, 30 ml of ethanol and 300 ml of 6N hydrochloric acid. The mixture was refluxed for 1 hour. The reaction mixture was introduced into 3 liters of ice water. The resulting crystal was collected by filtration and recrystallized from ethanol to obtain 23.5 g (yield: 92.2%) of 7-amino-2,3-dihydro-6-phenoxy-4H-1-benzopyran-4-one having a melting point of 154°-155° C.

Workup

  1. temperatureThe mixture was refluxed for 1 hour
  2. filtrationThe resulting crystal was collected by filtration
  3. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-c2b05891d0ba47ecbef3775430a1c88a
Source dataset
uspto-grants-1990_09
Patent number
US04954518

Reaction notes

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