Hydrochloric Acid → HCID 11793855, compound

HRID 1031722Notes

Reaction equation

HRID 1031722 reaction equation
C([O:3][C:4]([C:6]1[O:7][C:8]2[CH:16]=[C:15]([NH:17][S:18]([CH3:21])(=[O:20])=[O:19])[C:14]([O:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:13][C:9]=2[C:10](=[O:12])[CH:11]=1)=[O:5])C.Cl.O>C(O)(=O)C>[C:4]([C:6]1[O:7][C:8]2[CH:16]=[C:15]([NH:17][S:18]([CH3:21])(=[O:20])=[O:19])[C:14]([O:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[CH:13][C:9]=2[C:10](=[O:12])[CH:11]=1)([OH:5])=[O:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 10621185HCID 10621185, compound

Product 1

HCID 11793855HCID 11793855, compoundYield 92.1%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

3.5 g of 2-ethoxycarbonyl-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one was suspended in 30 ml of acetic acid. Thereto was added 20 ml of concentrated hydrochloric acid. The mixture was refluxed for 1 hour. To the reaction mixture was added 100 ml of water. The resulting crystal was collected by filtration and then recrystallized from ethanol to obtain 3.0 g (yield: 91%) of 2-carboxy-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one having a melting point of >250° C.

Workup

  1. temperatureThe mixture was refluxed for 1 hour
  2. filtrationThe resulting crystal was collected by filtration
  3. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-d6a0dd50ec434d5f8f60fd73ca485d75
Source dataset
uspto-grants-1990_09
Patent number
US04954518

Reaction notes

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