HCID 13919018, compound → HCID 53802334, compound

HRID 1031777Notes

Reaction equation

HRID 1031777 reaction equation
[CH:1]([N:3]1[CH2:12][CH2:11][C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2/[C:4]/1=[CH:13]/[C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1)=[O:2]>P.[Ru]>[CH:1]([N:3]1[CH2:12][CH2:11][C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[C:4]1=[CH:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1)=[O:2]

Participants

3

Reactant 1

HCID 13919018HCID 13919018, compound

Product 1

HCID 53802334HCID 53802334, compound

Reagents, catalysts & solvents 1

HCID 57454890HCID 57454890, compoundCatalyst

Procedure

Using each of the ruthenium-phosphine complexes obtained in Examples 2 to 16, the asymmetric hydrogenation reaction of (Z)-N-formyl-1-(4-methoxyphenylmethylene)- 3,4,5,6,7,8-hexahydroisoquinoline was carried out in the same reaction procedures as in Use Example 1 to produce (+)-N-formyl-1-(4-methoxyphenylmethylene)-1,2,3,4,5,6,7,8-octahydroisoquinoline. The results are shown in table 2.

Workup

  1. customwas carried out in the same reaction procedures as in Use Example 1

Sources & evidence

ORD record
ord-eb44c81bd3ad4fc99e998629921d6ebb
Source dataset
uspto-grants-1990_09
Patent number
US04954644

Reaction notes

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