Sodium Bicarbonate → HCID 19979812, compound

HRID 1031833Notes

Reaction equation

HRID 1031833 reaction equation
C(=O)(O)[O-].[Na+].[C:6]1(O)[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9](O)=[N:8][N:7]=1.[CH2:18]([S:26][S:27]C(=N)N)[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>O.CO>[CH2:18]([S:26][S:27][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([S:27][S:26][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[N:8][N:7]=1)[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

Participants

6

Reactant 3

HCID 516892Sodium BicarbonateHCID 19979809HCID 19979809, compoundHCID 178518942HCID 178518942, compound

Product 1

HCID 19979812HCID 19979812, compoundYield 91%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of sodium bicarbonate (4.30 8, 0.05 mole) in water (60 ml) was added dropwise to a stirred suspension of the phthalazine-1,4-diol prepared as above (2.91 g, 0.015 mole) and S-n-octylthioisothiourea obtained in step (A) (7.695 g, 0.03 mole) in methanol (70 ml) at 60°-65° C. over 30 minutes. The mixture was stirred at room temperature for a further hour, then filtered giving a yellow solid, which was washed with water and dried giving the duct as yellow crystals (6.56 g, 91%).

Workup

  1. filtrationfiltered
  2. customgiving a yellow solid, which
  3. washwas washed with water
  4. customdried

Sources & evidence

ORD record
ord-49dfbd82878d4098a63329f4f27bb224
Source dataset
uspto-grants-1990_09
Patent number
US04956118

Reaction notes

Loading…