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HRID1031862

反应详情

EQUATION

反应方程式

HRID 1031862 的结构方程式

REACTANTS

反应物

2
结构：NCc1ccc(Cl)cc1
HCID66036

4-Chlorobenzylamine

C7H8ClN

结构：Cc1ccc(S(=O)(=O)OC[C@H]2O[C@@H](n3cc(C)c(=O)[nH]c3=O)C[C@@H]2O)cc1
HCID7302460

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cn([C@H]2C[C@H](O)[C@@H](CNCc3ccc(Cl)cc3)O2)c(=O)[nH]c1=O
HCID54431387

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

A solution of 396 mg of 5'-O-(p-toluenesulphonyl)-thymidine and 1.5 ml of 4-chlorobenzylamine in 2 ml of DMF was stirred at 80° C. for 2 hours. The solvent was removed by evaporation and the residue was triturated with diethyl ether. The resulting solid was recrystallized from ethanol to yield 56 mg of 5'-(4-chlorobenzylamino)-5'-deoxythymidine, mp 179°-180° C.

WORKUP

后处理

  1. customThe solvent was removed by evaporation
  2. customthe residue was triturated with diethyl ether
  3. customThe resulting solid was recrystallized from ethanol