Morpholine → HCID 14421320, compound

HRID 1031878Notes

Reaction equation

HRID 1031878 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[N:9]=[C:8](Cl)[CH:7]=[CH:6][N:5]=1.[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>ClCCl>[CH3:1][O:2][CH2:3][C:4]1[N:9]=[C:8]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[CH:7]=[CH:6][N:5]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 14306130105950-89-8

Product 1

HCID 14421320HCID 14421320, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 12 g of 2-methoxymethyl-4-chloropyrimidine and 15 ml of morpholine in 50 ml of dichloromethane was stirred at room temperature for 3 hours. The reaction solution was washed several times with water. The organic phase was dried and, after purification by column chromatography, yielded 13 g of 2-methoxymethyl4-morpholinopyrimidine as an oil.

Workup

  1. washThe reaction solution was washed several times with water
  2. customThe organic phase was dried
  3. customafter purification by column chromatography

Sources & evidence

ORD record
ord-2f69a80f6c1345c985a5b9f9eb515549
Source dataset
uspto-grants-1990_09
Patent number
US04956366

Reaction notes

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