反应详情

50 g of 6-hydroxy-4-methoxymethylpyrimidine were heated in 375 ml of phosphorus oxychloride until a clear solution had been produced. The excess phosphorus oxychloride was removed by distillation in vacuo, and the residue was poured into ice-water. Extraction with dichloromethane and drying over sodium sulfate were followed by concentration of the solution in vacuo. 58 g of 6-chloro-4-methoxymethylpyrimidine were obtained as an oil which was used without further purification in the next stage.

1. customhad been produced
2. customThe excess phosphorus oxychloride was removed by distillation in vacuo
3. additionthe residue was poured into ice-water
4. extractionExtraction with dichloromethane
5. dry with materialdrying over sodium sulfate