反应详情

Phenylisocyanate (1.05 ml) was added dropwise to a solution of N-[4-(2-diethylaminoethoxy)phenyl]-4,5-dihydro-1-phenyl-1H-pyrazol-3-amine (2.4 g) in tetrahydrofuran (30 ml) and the solution heated to reflux for 4 hours. After cooling the solvent was removed and water added to the residue, which was then extracted with ether. The combined ether layer was washed with water and dried. Solvent was removed to give a solid which was recrystallised from ethyl acetate and petroleum ether to give the title compound (1.3 g) mp 140°-1°.

1. temperaturethe solution heated
2. temperatureto reflux for 4 hours
3. temperatureAfter cooling the solvent
4. customwas removed
5. additionwater added to the residue, which
6. extractionwas then extracted with ether
7. washThe combined ether layer was washed with water
8. customdried
9. customSolvent was removed
10. customto give a solid which
11. customwas recrystallised from ethyl acetate and petroleum ether