Sulfuric Acid → HCID 14422913, compound

HRID 1032017Notes

Reaction equation

HRID 1032017 reaction equation
[C:1]([CH2:4][C:5]1[C:14]([F:15])=[C:13]2[C:8]([C:9](=[O:22])[C:10]([C:19]([OH:21])=[O:20])=[CH:11][N:12]2[CH:16]2[CH2:18][CH2:17]2)=[CH:7][C:6]=1[F:23])(=[O:3])N.S(=O)(=O)(O)[OH:25].N([O-])=O.[Na+]>>[CH:16]1([N:12]2[C:13]3[C:8](=[CH:7][C:6]([F:23])=[C:5]([CH2:4][C:1]([OH:25])=[O:3])[C:14]=3[F:15])[C:9](=[O:22])[C:10]([C:19]([OH:21])=[O:20])=[CH:11]2)[CH2:18][CH2:17]1

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 144229127-Carbamoylmethyl-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acidHCID 23668193Sodium Nitrite

Product 1

HCID 14422913HCID 14422913, compound

Procedure

3.0 g of the compound from Example 10 are warmed to 90°-100° C. in 17 ml of 30% strength sulphuric acid. At this temperature, 6 ml of 2.5 molar sodium nitrite solution are added dropwise. The mixture is stirred for one hour more at 100° and then cooled. The precipitated solid is isolated, washed and dried.

Workup

  1. temperaturecooled
  2. customThe precipitated solid is isolated
  3. washwashed
  4. customdried

Sources & evidence

ORD record
ord-2efa60f6623641e884e7eb6e71cec217
Source dataset
uspto-grants-1990_09
Patent number
US04956465

Reaction notes

Loading…