Aniline → HCID 14796243, compound

HRID 1032231Notes

Reaction equation

HRID 1032231 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9]([NH:11][C:12](=[O:14])[CH:13]=1)=[O:10].[NH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:12](=[O:14])[NH:11][C:9]1=[O:10]

Participants

4

Reactant 2

HCID 6115AnilineHCID 21924318HCID 21924318, compound

Product 1

HCID 14796243HCID 14796243, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-(2-chlorophenyl)maleimide (4.70 g) and aniline (3.069) in ethanol (50 ml) is refluxed for 38 hours. The reaction mixture is concentrated and the residue is subjected to silica gel chromatography, with elution being carried out with n-hexane-ethyl acetate (4:1-1:1) to give 2-(2-chlorophenyl)-3-anilinosuccinimide (oil) (3.71 g)

Workup

  1. concentrationThe reaction mixture is concentrated
  2. washthe residue is subjected to silica gel chromatography, with elution

Sources & evidence

ORD record
ord-dd0820b6479c42e990c085a68d480679
Source dataset
uspto-grants-1990_09
Patent number
US04957537

Reaction notes

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