2-Methylimidazole → HCID 22165200, compound

HRID 1032245Notes

Reaction equation

HRID 1032245 reaction equation
Cl.CN([CH2:5][CH:6]1[C:11](=[O:12])[CH:10]=[C:9]([NH:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[I:21])[CH2:8][CH2:7]1)C.[CH3:22][C:23]1[NH:24][CH:25]=[CH:26][N:27]=1>CN(C)C=O>[I:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[CH2:14][NH:13][C:9]1[CH2:8][CH2:7][CH:6]([CH2:5][N:24]2[CH:25]=[CH:26][N:27]=[C:23]2[CH3:22])[C:11](=[O:12])[CH:10]=1

Participants

4

Reactant 2

HCID 127492-MethylimidazoleHCID 22165202HCID 22165202, compound

Product 1

HCID 22165200HCID 22165200, compoundYield 43.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of the product of Stage (ii) (350 mg) and 2-methylimidazole (350 mg) in dry dimethylformamide (25 ml) was heated at 100° under nitrogen for 24 h. The cooled reaction mixture was evaporated in vacuo and purified by flash chromatography (C) to give, as the second eluted major component, the title compound (153 mg) as a gum. T.l.c. (C), Rf 0.35

Workup

  1. temperaturewas heated at 100° under nitrogen for 24 h
  2. customThe cooled reaction mixture
  3. customwas evaporated in vacuo
  4. custompurified by flash chromatography (C)
  5. customto give, as the second eluted major component

Sources & evidence

ORD record
ord-e788854334244111aab73e4ccdee085c
Source dataset
uspto-grants-1990_09
Patent number
US04957609

Reaction notes

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