Hydrazine hydrate (1:1) → HCID 178429564, compound

HRID 1032256Notes

Reaction equation

HRID 1032256 reaction equation
C1(=O)[N:5]([CH2:6][CH2:7][C:8]2[NH:12][C:11]3[CH:13]=[CH:14][C:15]([C:17]4[CH:18]([CH3:24])[CH2:19][C:20](=[O:23])[NH:21][N:22]=4)=[CH:16][C:10]=3[N:9]=2)C(=O)C2=CC=CC=C12.O.NN>>[NH2:5][CH2:6][CH2:7][C:8]1[NH:12][C:11]2[CH:13]=[CH:14][C:15]([C:17]3[CH:18]([CH3:24])[CH2:19][C:20](=[O:23])[NH:21][N:22]=3)=[CH:16][C:10]=2[N:9]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178429563HCID 178429563, compound

Product 1

HCID 178429564HCID 178429564, compound

Procedure

##STR68## Prepared by a method analogous to that of Example 1d) from 1.44 g (3.6 mmol) of 6-[2-(2-phthalimidoethyl)-1H-benzimidazol-5-yl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone and 0.9 ml (18 mmol) of hydrazine hydrate. The crude product is chromatographed on silica gel with methanol/conc. ammonia (99:1). After concentration of the main fraction by evaporation under vacuum and crystallization of the residue from ethanol, 0.55 g (51%) of a colourless solid melting at 178° C. are obtained.

Workup

  1. customThe crude product is chromatographed on silica gel with methanol/conc
  2. customAfter concentration of the main fraction by evaporation
  3. customunder vacuum and crystallization of the residue from ethanol, 0.55 g (51%) of a colourless solid melting at 178° C.
  4. customare obtained

Sources & evidence

ORD record
ord-d5fc770f64664640ab2f936d7a9eeab8
Source dataset
uspto-grants-1990_09
Patent number
US04957920

Reaction notes

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