Potassium Iodide → HCID 14556323, compound

HRID 1032339Notes

Reaction equation

HRID 1032339 reaction equation
Br[CH:2]([C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=1)[C:3]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][CH:4]=1.[Br:17][CH2:18][CH2:19][CH2:20][OH:21].C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+]>O>[F:9][C:6]1[CH:7]=[CH:8][C:3]([CH:2]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[O:21][CH2:20][CH2:19][CH2:18][Br:17])=[CH:4][CH:5]=1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 123083-Bromo-1-propanolHCID 676651,1'-(Bromomethylene)bis(4-fluorobenzene)

Product 1

HCID 14556323HCID 14556323, compoundYield 68.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 36.9 g (0.130 mole) of bromobis(4-fluorophenyl)methane, 21.7 g (0.156 mole) of 3-bromopropanol, 16.6 g (0.156 mole) of sodium carbonate and a few potassium iodide crystals were heated to 130° C. for 16 hours. After cooling, the reaction mixture was diluted with water and extracted with ether. The ethereal phase was washed with water, dried on sodium sulfate and then concentrated to dryness. Distillation of the residue yielded 30.5 g (yield: 68%) of the desired propane.

Workup

  1. temperatureAfter cooling
  2. extractionextracted with ether
  3. washThe ethereal phase was washed with water
  4. customdried on sodium sulfate
  5. concentrationconcentrated to dryness
  6. distillationDistillation of the residue

Sources & evidence

ORD record
ord-a0e664139cd24e3b8ea7721e27018984
Source dataset
uspto-grants-1990_09
Patent number
US04957927

Reaction notes

Loading…