Potassium Carbonate → HCID 14556317、化合物

反応式

[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[O:9][CH2:10][CH2:11]Br)=[CH:4][CH:3]=1.[CH3:20][O:21][C:22]1[CH:23]=[C:24]([CH:28]2[CH2:32][CH2:31][CH2:30][NH:29]2)[CH:25]=[CH:26][CH:27]=1.C(=O)([O-])[O-].[K+].[K+]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[O:9][CH2:10][CH2:11][N:29]2[CH2:30][CH2:31][CH2:32][CH:28]2[C:24]2[CH:25]=[CH:26][CH:27]=[C:22]([O:21][CH3:20])[CH:23]=2)=[CH:4][CH:3]=1

参加物

反応物 3

HCID 11430Potassium Carbonate

HCID 36138242-(3-Methoxyphenyl)pyrrolidine

HCID 105681861-Bromo-2-[bis(4-fluorophenyl)methoxy]ethane

生成物 1

HCID 14556317HCID 14556317、化合物収率 52%

実験手順

Proceeding as in Example 9, using 9.8 g (30 mmole) of 1-[bis(4-fluorophenyl)methoxy]-2-bromoethane, 5.3 g (30 mmole) of (2-(3-methoxyphenyl)pyrrolidine and 8.3 g (60 mmole) of potassium carbonate, there was obtained after silica gel column filtration, 6.7 g (yield: 52%) of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-2-(3-methoxyphenyl)pyrrolidine.

後処理

customthere was obtained

出典と根拠

ORDレコード: ord-54d5a1f10e0848908615873d78167e69
出典データセット: uspto-grants-1990_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04957927

反応ノート

読み込み中…