Thionyl Chloride → (Diphenylmethoxy) acetyl chloride

HRID 1032343Notes

Reaction equation

HRID 1032343 reaction equation
S(Cl)([Cl:3])=O.[C:5]1([CH:11]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[O:12][CH2:13][C:14](O)=[O:15])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C1C=CC=CC=1>[C:5]1([CH:11]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[O:12][CH2:13][C:14]([Cl:3])=[O:15])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 597513Benzhydryloxyacetic acid

Product 1

HCID 13111194(Diphenylmethoxy) acetyl chlorideYield 73%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

8.1 g (68.1 mmole) of thionyl chloride was added to a solution of 5.5 g (22.7 mmole) of (diphenylmethoxy) acetic acid in 150 cm3 of benzene. The solution was refluxed for 5 hours, then evaporated to dryness under reduced pressure. Distillation of the residue yielded 4.3 g (yield: 73%) of (diphenylmethoxy) acetyl chloride.

Workup

  1. temperatureThe solution was refluxed for 5 hours
  2. customevaporated to dryness under reduced pressure
  3. distillationDistillation of the residue

Sources & evidence

ORD record
ord-522973b92c3346e4b8cedce66aaf0cba
Source dataset
uspto-grants-1990_09
Patent number
US04957927

Reaction notes

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