Water → HCID 22165505, compound

HRID 1032356Notes

Reaction equation

HRID 1032356 reaction equation
[C:1]([O:4][CH2:5][C:6](=[O:9])[CH2:7][OH:8])(=[O:3])[CH3:2].[O-:10][C:11]#[N:12].[Na+].FC(F)(F)C(O)=O.O>C1C=CC=CC=1>[C:1]([O:4][CH2:5][C:6](=[O:9])[CH2:7][O:8][C:11](=[O:10])[NH2:12])(=[O:3])[CH3:2]

Participants

6

Reactant 4

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 517096Sodium CyanateHCID 18702505HCID 18702505, compound

Product 1

HCID 22165505HCID 22165505, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a stirred mixture of 1-acetoxy-3-hydroxy-2-propanone (10.8 g., 0.1 mole) and sodium cyanate (13.0 g., 0.2 mole) in benzene (50 ml.) is slowly added trifluoroacetic acid (15.5 ml., 0.21 mole). The reaction mixture is stirred for three hours, then water (15 ml.) is added. The organic layer is separated, dried and the solvent removed under reduced pressure to afford 1-acetoxy-3-carbamoyloxy-2-propanone.

Workup

  1. customThe organic layer is separated
  2. customdried
  3. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-d8981ebb25474888bcd8ca6a90825c26
Source dataset
uspto-grants-1990_09
Patent number
US04957912

Reaction notes

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