Ethyl Acetate → HCID 13535401, compound

Participants

Reaction Steps

The 1-(4-chlorophenoxy) 3-(1,2,4-triazol-1-yl)propan-2 ol (3.0g) was dissolved in acetone (100ml) and treated with Jones reagent (3ml) for 3 h. To complete the oxidation, two subsequent additions of Jones reagent (0.5ml) were added. After cooling, ethyl acetate (150ml) was added and the reaction was neutralised by the addition of a saturated solution of sodium bicarbonate. The organic phase was separated, washed with water, dried and concentrated to dryness under reduced pressure. The residue was purified by chromatography on silica using 2% by volume methenol in chloroform as eluent, to give 1-(4-chlorophenoxy)-3-(1,2,4-triazol -1-yl)propan-2-one as a gum, NMR in deuteriochloroform: δ4.7(2H,s), 5.38(2H,s), 6.85(2H,d), 7.3(2H,d), 8.01(1H,s), 8.17(1H,s).

Provenance & Evidence