反应详情

To 1.0 g (3.13 mmol) of N-benzyl-5,6-dimethoxy-N-methylisoindolinium chloride, 10 ml of 48% hydrobromic acid was added, and the mixture was heated at reflux for 3 hours at an external temperature of from 110° to 130° C. The reaction solution was evaporated to dryness under reduced pressure, and the crystal residue was washed with 10 ml of acetone to obtain 1.05 g of the above identified compound.

1. temperaturethe mixture was heated
2. temperatureat reflux for 3 hours at an external temperature of from 110° to 130° C
3. customThe reaction solution was evaporated to dryness under reduced pressure
4. washthe crystal residue was washed with 10 ml of acetone
5. customto obtain 1.05 g of the