(4-Benzyloxy-3-nitrophenyl)acetonitrile → (3-Amino-4-benzyloxyphenyl)acetonitrile

HRID 1032515ノート

反応式

HRID 1032515 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]#[N:17])=[CH:11][C:10]=1[N+:18]([O-])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>[Ni].CO>[NH2:18][C:10]1[CH:11]=[C:12]([CH2:15][C:16]#[N:17])[CH:13]=[CH:14][C:9]=1[O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 13629303(4-Benzyloxy-3-nitrophenyl)acetonitrileHCID 178418361HCID 178418361、化合物

生成物 1

HCID 22165986(3-Amino-4-benzyloxyphenyl)acetonitrile収率 76.7%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

In the presence of Raney nickel, 53.6 g of (4-benzyloxy-3-nitrophenyl)acetonitrile in 1.2 1 of methanol is hydrogenated until 12.2 1 of hydrogen has been absorbed. The crude product obtained after removing the catalyst by filtration and after evaporation is purified by chromatography on silica gel with cyclohexane/ethyl acetate (1:1), thus obtaining 36.5 g of (3-amino-4-benzyloxyphenyl)acetonitrile as an oil.

後処理

  1. customhas been absorbed
  2. customThe crude product obtained
  3. customafter removing the catalyst
  4. filtrationby filtration
  5. customafter evaporation
  6. customis purified by chromatography on silica gel with cyclohexane/ethyl acetate (1:1)

出典と根拠

ORDレコード
ord-d58da132a73e4c47ac43e5600e2d7cee
出典データセット
uspto-grants-1990_09
特許番号
US04958026

反応ノート

読み込み中…