Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(4-Benzyloxy-3-nitrophenyl)acetonitrile → (3-Amino-4-benzyloxyphenyl)acetonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (4-Benzyloxy-3-nitrophenyl)acetonitrile | HCID 13629303 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Nickel | HCID 935 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (3-Amino-4-benzyloxyphenyl)acetonitrile | HCID 22165986 | 76.7% |
반응 단계
In the presence of Raney nickel, 53.6 g of (4-benzyloxy-3-nitrophenyl)acetonitrile in 1.2 1 of methanol is hydrogenated until 12.2 1 of hydrogen has been absorbed. The crude product obtained after removing the catalyst by filtration and after evaporation is purified by chromatography on silica gel with cyclohexane/ethyl acetate (1:1), thus obtaining 36.5 g of (3-amino-4-benzyloxyphenyl)acetonitrile as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04958026 |
| 출처 데이터셋 | uspto-grants-1990_09 |
| ORD ID | ord-d58da132a73e4c47ac43e5600e2d7cee |
| 출처 메모 | uspto-grants-1990_09 |