Hydrochloric Acid → HCID 178491085, compound

HRID 1032532Notes

Reaction equation

HRID 1032532 reaction equation
[OH:1][C:2]1[C:10]2[C:5](=[C:6]([O:20][CH3:21])[CH:7]=[C:8]([CH2:11][CH2:12][NH:13]C(=O)C(F)(F)F)[CH:9]=2)[NH:4][N:3]=1.[ClH:22].Cl.OC1C2C(=C(OC)C=CC=2CCN)NN=1>C(O)C.C(OCC)C>[ClH:22].[OH:1][C:2]1[C:10]2[C:5](=[C:6]([O:20][CH3:21])[CH:7]=[C:8]([CH2:11][CH2:12][NH2:13])[CH:9]=2)[NH:4][N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 178490290HCID 178490290, compoundHCID 178491205HCID 178491205, compound

Product 1

HCID 178491085HCID 178491085, compound

Reagents, catalysts & solvents 1

HCID 21585056Diethyl ether ethanolSolvent

Procedure

2.7 g of N-[2-(3-hydroxy-7-methoxy-1H-indazol-5-yl)ethyl]trifluoroacetamide is refluxed with hydrochloric acid as disclosed in the preparation of 2-(3-hydroxy-7-methoxy-1H-indazol-4-yl)ethylamine, hydrochloride, thus obtaining by crystallization from ethanol/diethyl ether 1.5 g of 2-(3-hydroxy-7-methoxy-1H-indazol-5-yl)ethylamine, hydrochloride, decomposition point 266°-268° C.

Sources & evidence

ORD record
ord-07e158784f084aa68612865f4ac450c7
Source dataset
uspto-grants-1990_09
Patent number
US04958026

Reaction notes

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