Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1032544Generated: October 25, 2026

2-(7-nitro-1H-indazol-4-yl)acetonitrile → 2-(7-amino-1H-indazol-4-yl)acetonitrile

https://huagongshe.com/reaction/1032544

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(7-nitro-1H-indazol-4-yl)acetonitrileHCID 13629308—
CatalystNickelHCID 935—
SolventTetrahydrofuranHCID 8028—
Product2-(7-amino-1H-indazol-4-yl)acetonitrileHCID 1935443487.8%

Reaction Steps

20.2 g of 2-(7-nitro-1H-indazol-4-yl)-acetonitrile in 750 ml of tetrahydrofuran is hydrogenated in the presence of 20.0 g of Raney nickel. The product is recrystallized from tetrahydrofuran/hexane, yielding 15.1 g of 2-(7-amino-1H-indazol-4-yl)acetonitrile, mp 164°-165° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04958026
Source datasetuspto-grants-1990_09
ORD IDord-eb4a0d8baa674734875fca2f76128da7
Source noteuspto-grants-1990_09