Hydrogen Bromide → HCID 178419705, compound

HRID 1032549Notes

Reaction equation

[OH:1][C:2]1[C:10]2[C:5](=[C:6]([O:18]C)[CH:7]=[CH:8][C:9]=2[C:11](F)(F)[C:12]([NH:14]F)=O)[NH:4][N:3]=1.[BrH:20]>>[BrH:20].[OH:1][C:2]1[C:10]2[C:5](=[C:6]([OH:18])[CH:7]=[CH:8][C:9]=2[CH2:11][CH2:12][NH2:14])[NH:4][N:3]=1

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 178490584HCID 178490584, compound

Product 1

HCID 178419705HCID 178419705, compound

Procedure

Under argon, 750 mg of N-[2-(3-hydroxy-7-methoxy-1H-indazol-4-yl]trifluoroacetamide is heated to 120° C. with 5 ml of aqueous hydrogen bromide (65%) for 2 hours. The crystallized product is recrystallized from methanol/diethyl ether, yielding 680 mg of 2-(3,7-dihydroxy-1H-indazol-4-yl)ethylamine, hydrobromide, decomposition point 270°-273° C.

Workup

customThe crystallized product is recrystallized from methanol/diethyl ether

Sources & evidence

ORD record: ord-6c953fc5fe904eceaee9fe5f2a3af890
Source dataset: uspto-grants-1990_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04958026

Reaction notes

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