Trifluoroacetic acid → HCID 178490304, compound

HRID 1032554Notes

Reaction equation

HRID 1032554 reaction equation
[NH2:1][C:2]1[C:7]([NH2:8])=[C:6]([O:9][CH3:10])[CH:5]=[CH:4][C:3]=1[CH2:11][CH2:12][N:13]([CH3:15])[CH3:14].[F:16][C:17]([F:22])([F:21])[C:18](O)=O>>[CH3:10][O:9][C:6]1[C:7]2[N:8]=[C:18]([C:17]([F:22])([F:21])[F:16])[NH:1][C:2]=2[C:3]([CH2:11][CH2:12][N:13]([CH3:15])[CH3:14])=[CH:4][CH:5]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 13771317HCID 13771317, compound

Product 1

HCID 178490304HCID 178490304, compound

Procedure

600 mg of N-[2-(2,3-diamino-4-methoxyphenyl)ethyl]-N,N-dimethylamine is heated under reflux for 3 hours with 10 ml of trifluoroacetic acid. After concentration, the residue is recrystallized from isopropanol, thus obtaining 908 mg of 7-methoxy-4-[2-(N,N-dimethylamino)ethyl]-2-trifluoromethylbenzimidazole, trifluoroacetate, mp 182°-185° C.

Workup

  1. concentrationAfter concentration
  2. customthe residue is recrystallized from isopropanol

Sources & evidence

ORD record
ord-893c7b833b6b4387b614a8b3d7ac4e8e
Source dataset
uspto-grants-1990_09
Patent number
US04958026

Reaction notes

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