HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → Benzoyl chloride, 2,4-dichloro-5-fluoro-3-nitro-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2,4-Dichloro-5-fluoro-3-nitrobenzoic acid | HCID 2734259 | — |
| Product | Benzoyl chloride, 2,4-dichloro-5-fluoro-3-nitro- | HCID 11818130 | — |
Reaction Steps
106.6 g of 2,4-dichloro-5-fluoro-3-nitrobenzoic acid are heated to boiling under reflux with 250 ml of thionyl chloride for 2 hours. The excess thionyl chloride is then removed by distillation under atmospheric pressure, and the residue is fractionated under high vacuum. 104.7 g of 2,4-dichloro-5-fluoro-3-nitrobenzoylchloride distil over at 110°-115° C./0.08-0.09 mbar. Crystals of melting point 35°-37° C. form on standing.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04958045 |
| Source dataset | uspto-grants-1990_09 |
| ORD ID | ord-5f4fe67ee3784ff698ab2310b3250e96 |
| Source note | uspto-grants-1990_09 |