反应详情

温度

55 °C

8.7g (0.05 m) of hexanoylacetic acid and 12.7 g (0.10m) of oxalyl chloride were mixed together at room temperature. The reaction was heated gradually over one hour to 50-60° C., then to 60-70° C. under aspirator pressure for one hour. The reaction mixture was diluted with 125 ml hexane, washed with 3×100 ml ice water, dried over 20 g MgSO4, and roto-vapped at 50° C. to yield an oil (9.4 g, 98% yield).

1. washwashed with 3×100 ml ice water
2. dry with materialdried over 20 g MgSO4