Triethylamine → HCID 15056299, compound

HRID 1032652Notes

Reaction equation

HRID 1032652 reaction equation
[O:1]=[C:2]([N:5]1[CH2:10][CH2:9][N:8]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:7][CH2:6]1)[CH:3]=[CH2:4].C(N(CC)CC)C.[SH:25][C:26]1[CH:27]=[C:28]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)[C:29]([OH:38])=[C:30]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:31]=1>CO>[OH:38][C:29]1[C:28]([C:39]2[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=2)=[CH:27][C:26]([S:25][CH2:4][CH2:3][C:2]([N:5]2[CH2:6][CH2:7][N:8]([CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH2:9][CH2:10]2)=[O:1])=[CH:31][C:30]=1[C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 149891685'-Mercapto[1,1':3',1"-terphenyl]-2'-olHCID 150562931-(1-Oxo-2-propenyl)-4-(phenylmethyl)piperazine

Product 1

HCID 15056299HCID 15056299, compoundYield 29.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Following the procedure of Example 4, 1-(1-oxo-2-propenyl-4-phenylmethyl)piperazine (Example 8) (2.30 g, 0.01 mole) was dissolved in methanol (150 ml) and triethylamine (1 ml) added to the solution. The solution was flushed with argon several times, 5'-mercapto [1,1':3',1"-terphenyl]-2'-ol (2.77 g, 0.01 mole) added and the reaction stirred for 12 hours. The solvent was removed and the product isolated by chromatography to yield 1.5 g of product after drying in vacuo.

Workup

  1. additionadded
  2. customThe solvent was removed
  3. customthe product isolated by chromatography

Sources & evidence

ORD record
ord-fb865aedf2ab4ae3a137eef5fdf5febb
Source dataset
uspto-grants-1990_09
Patent number
US04959364

Reaction notes

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