反应详情

[2-[(5-Bromopentyl)oxy]ethyl]benzene (10.0 g) was added over 1 h to benzylamine (30 ml) at ca. 120° under nitrogen. After 2 h at 120° the reaction mixture was added to 2N hydrochloric acid (200 ml), the mixture was extracted with ethyl acetate (2×250 ml) and the combined organic extracts were washed with 2N sodium carbonate, water and brine, dried and concentrated in vacuo to give the title compound as a pale yellow oil (8.6 g), t.l.c. (ethyl acetate-triethylamine 99:1) Rf 0.78

1. extractionthe mixture was extracted with ethyl acetate (2×250 ml)
2. washthe combined organic extracts were washed with 2N sodium carbonate, water and brine
3. customdried
4. concentrationconcentrated in vacuo