HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1032715Generated: October 25, 2026
Water → 2-Fluoro-4-(pyridin-4-yl)benzoic acid
https://huagongshe.com/reaction/1032715
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Permanganate | HCID 516875 | — |
| Reactant | 4-(3-Fluoro-4-methylphenyl)-1-trimethylacetyl-1,4-dihydropyridine | HCID 14851973 | — |
| Product | 2-Fluoro-4-(pyridin-4-yl)benzoic acid | HCID 10443327 | — |
Reaction Steps
The product of part (a) (75.0 g) in 2 L water was heated on a steam bath, and 200 g potassium permanganate was added portion-wise. The reaction mixture was heated at 100° C. for three days and then filtered to remove manganese oxide. The filtrate was concentrated in vacuo and the residue dried to give 36.1 g of 2-fluoro-4-(4pyridinyl)benzoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04959363 |
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| Source dataset | uspto-grants-1990_09 |
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| ORD ID | ord-ae8b164836c041b4837f1ca4298b3c5b |
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| Source note | uspto-grants-1990_09 |
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