Water → 2-Fluoro-4-(pyridin-4-yl)benzoic acid

HRID 1032715노트

반응식

HRID 1032715 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH:14]=[CH:13][N:12](C(=O)C(C)(C)C)[CH:11]=[CH:10]2)[CH:5]=[CH:6][C:7]=1[CH3:8].[Mn]([O-])(=O)(=O)=[O:22].[K+].[OH2:27]>>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[C:8]([OH:22])=[O:27]

참가 물질

4

반응물 3

HCID 962WaterHCID 516875Potassium PermanganateHCID 148519734-(3-Fluoro-4-methylphenyl)-1-trimethylacetyl-1,4-dihydropyridine

생성물 1

HCID 104433272-Fluoro-4-(pyridin-4-yl)benzoic acid

반응 조건

온도
100 °C

실험 절차

The product of part (a) (75.0 g) in 2 L water was heated on a steam bath, and 200 g potassium permanganate was added portion-wise. The reaction mixture was heated at 100° C. for three days and then filtered to remove manganese oxide. The filtrate was concentrated in vacuo and the residue dried to give 36.1 g of 2-fluoro-4-(4pyridinyl)benzoic acid.

후처리

  1. filtrationfiltered
  2. customto remove manganese oxide
  3. concentrationThe filtrate was concentrated in vacuo
  4. customthe residue dried

출처 및 근거

ORD 기록
ord-ae8b164836c041b4837f1ca4298b3c5b
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04959363

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