1-(4-Fluorophenyl)-4-oxo-7-(4-pyridyl)quinoline-3-carboxamide → 1-Ethyl-4-oxo-7-(2-pyridyl)quinoline-3-carboxamide

HRID 1032722Notes

Reaction equation

HRID 1032722 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=3)[CH:11]=2)[C:6](=[O:19])[C:5]([C:20]([OH:22])=O)=[CH:4]1)[CH3:2].FC1C=CC([N:30]2C3C(=CC=C(C4C=CN=CC=4)C=3)C(=O)C(C(N)=O)=C2)=CC=1>>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=3)[CH:11]=2)[C:6](=[O:19])[C:5]([C:20]([NH2:30])=[O:22])=[CH:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 4433701-(4-Fluorophenyl)-4-oxo-7-(4-pyridyl)quinoline-3-carboxamideHCID 103346241-Ethyl-1,4-dihydro-4-oxo-7-(2-pyridinyl)-3-quinolinecarboxylic acid

Product 1

HCID 4787191-Ethyl-4-oxo-7-(2-pyridyl)quinoline-3-carboxamide

Procedure

[I; R=H, R1C2H5, R2H, R6H, R7 -pyridinyl] was prepared from 2.94 g 1-ethyl-1,4-dihydro-4-oxo-7-(2-pyridinyl)-3-quinolinecarboxylic acid (U.S. Pat No. 3,753,993) according to the procedure of Example 1, part (h), and was obtained (2.66 g) in the form of a light-tan solid, m.p. 245°-246° C.

Workup

  1. customwas obtained (2.66 g) in the form of a light-tan solid, m.p. 245°-246° C.

Sources & evidence

ORD record
ord-5f7d5b650d20457d980bf53c2eb6b3ba
Source dataset
uspto-grants-1990_09
Patent number
US04959363

Reaction notes

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