HCID 11194588, compound → HCID 14851848, compound

HRID 1032755Notes

Reaction equation

HRID 1032755 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16](I)[CH:17]=[CH:18][C:13]=2[N:12]2[C:20]([CH3:23])=[N:21][N:22]=[C:11]2[CH2:10][N:9]=1.[CH2:24]([N:27]1[CH2:35][C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[C:28]1=[O:36])[C:25]#[CH:26]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[C:16]([C:26]#[C:25][CH2:24][N:27]3[CH2:35][C:34]4[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=4)[C:28]3=[O:36])[CH:17]=[CH:18][C:13]=2[N:12]2[C:20]([CH3:23])=[N:21][N:22]=[C:11]2[CH2:10][N:9]=1

Participants

3

Reactant 2

HCID 11194588HCID 11194588, compoundHCID 14851835HCID 14851835, compound

Product 1

HCID 14851848HCID 14851848, compound

Procedure

Reaction of 6-(2-fluorophenyl)-8-iodo-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine with 2,3-dihydro-(2-propynyl)-1H-isoindol-1-one [ref. J. I. Neumeyer, U. V. Moyer, J. A. Richman, F. J. Rosenberg and D. G. Teiger, J. Med. Chem. 10, 615 (1967)] gave after chromatographic purification as described in example 17 and crystallization from ethyl acetate colorless crystals of the title compound with m.p. 165°-168° C. According to spectral and analytical data, these crystals contained 0.5 molar amounts of water and traces of ethyl acetate.

Workup

  1. custom10, 615 (1967)] gave
  2. customafter chromatographic purification
  3. customas described in example 17 and crystallization from ethyl acetate colorless crystals of the title compound with m.p. 165°-168° C

Sources & evidence

ORD record
ord-a411d5b69b2946b99f98fb2484c92745
Source dataset
uspto-grants-1990_09
Patent number
US04959361

Reaction notes

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